The emphasis in this edition of the bulletin is on a variety of multi-sectoral areas. This issue covers information on key achievements of the National Action Plan for Health Security(NAPHS) updates, progress report, the new flagship initiatives, the national public health emergency management forum, global One Health day-Ethiopia, field epidemiological investigations, the International Day of Clear Air, as well as one health activities across the country. Additionally, antimicrobial resistance awareness-raising initiatives, a workshop on situational awareness for health extension workers, the new COVID-19 directive, national environmental protection initiatives, and the SPAR 2022multisectorall workshop, are given emphasis to be covered.