The National One Health strategy that guides the actions for achieving the vision have been defined. One Health actors envision “Ethiopia with negligible risks and impacts of endemic, emerging and re-emerging health threats at the animal-environment-human interface.” Accordingly, the mission, or fundamental purpose, of the strategy is “to establish sustainable One Health coordination mechanisms at all levels for multidisciplinary and multisectoral engagement in the prevention, detection, and response to endemic, emerging and re-emerging health threats at the human, animal and environment interface”.