Starting in 2018, Johns Hopkins Center for Communication Programs (CCP) has been implementing Global Health Security Agenda (GHSA) activities in 22 woredas of three regions in Ethiopia: Amhara, Oromia, and Southern Nations, Nationalities and Peoples (SNNP). The goal of the project is to prevent and control the spread of priority zoonotic diseases (PZDs) by increasing healthy practices among communities and households in the intervention woredas. The project has provided trainings on community engagement for frontline community workers, primarily Health Extension Workers (HEWs) and Animal Health Workers (AHWs); developed and distributed community engagement tools such as cue cards that facilitate Interpersonal Communication (IPC); aired radio spots that promote healthy behavior change and gender equality; and facilitated community mobilization activities. This activity aims to assess the reach of health messages to target audiences and the effectiveness of the messages in improving knowledge, attitudes, and healthy practices focusing on the interventions from October 1, 2022, to September 30, 2023. A Lot Quality Assurance Sampling (LQAS) method was used for the assessment. A total of 456 (50% female) randomly sampled men and women were interviewed using a structured questionnaire in August 2023.